The dermatology increases the humidity of the skin with certain agents that contain urea. Non-surgically removed nails contain 40% urea in the closed dressing.

The carbon-14-exhalation test for the presence of Helicobacter pylori was tested using either urea 14 containing carbon-14 or carbon-13. Because H. pylori urease uses urea to make ammonia to increase the pH in its surrounding stomach. The same principle can also test similar bacteria that live in the animal's stomach.